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SEROLOGICAL
IMMUNE RESPONSES TO LEISHMANIA ANTIGENS IN VISCERAL
LEISHMANIASIS
Stephan Theinert¹ , Michael
Forgber¹ ²and Peter Walden*
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ABSTRACT: The rapid progress of the genome
sequencing projects for infectious agents including
Leishmania increasingly guides molecular immunology
research on immunodominant antigens for vaccines and new
immunological diagnostics. We have used molecular
genetic and proteomic approaches to map the overall
antigenicity of Leishmania parasites in visceral
leishmaniasis and to elucidate the immunological
properties of specific antigens including
immunodominance, variability and accessibility for
targeted immune responses.
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¹
Department
of Dermatology, Charité – Universitätsmedizin
Berlin, Humboldt University, Charitéplatz 1, 10117 Berlin,
Germany, Tel.: +49-30-450 518 031; Fax: +49-30-450 518 932
²
Current address: Lehrstuhl für Molekulare Tierzucht und
Biotechnologie, Genzentrum der LMU München, Feodor-Lynen
Str. 25, 81377 München, Germany.
* Corresponding author : e-mail : peter.walden@charite.de
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